RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-133b
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
PCR; immunohistochemistry
Target
CTGF
Pathway
NA
PubMed ID
Title
MiR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling
Year
2009
Function
"miR-133 directly downregulates CTGF, a key profibrotic protein, and thereby establish an important role for these miRNAs in the control of structural changes in the extracellular matrix of the myocardium.miR-133 and miR-32 in pathological left ventricular hypertrophy allowsCTGF levels to increase, which contributes to collagen synthesis."